Current Issue : July-September Volume : 2014 Issue Number : 3 Articles : 6 Articles
Tablet disintegration is an essential step for fast drug release. Disintegrants are substances or mixture of substances added in drug formulations which increases dispersion or breakup of tablets and capsules into smaller particles for fast dissolution. Fast dissolving, fast melting, chewable and orally dissolving or disintegrating tablets are solid dosage forms that disintegrate rapidly and dissolve in the mouth without water. These products have staying power in the marketplace because they have great appeal to consumers and increased compliance among users. The main challenge with orally disintegrating tablets is to develop tablet formulations having rapid disintegration, pleasant mouth feel and high breaking force for tablet robustness. The disintegration of dosage forms depends upon various physical factors of superdisintegrants percentage of disintegrants used, proportion of disintegrants used, compatibility with other excipients, and presence of surfactants and hardness of the tablets, nature of drug substances and mixing and types of addition. Mechanisms for tablet disintegration are swelling, porosity and capillary action (wicking), deformation, enzymatic reaction, due to disintegrating particle/particle repulsive forces, heat of wetting, due to release of gases and combination action. Natural Superdisintegrants includes mucilage of Isapghula Husk, Cress, Gum Karaya, Fenugreek Seed and gum of Locust Bean, Chitin and chitosan, Gellan, Agar, Alginates, Soy polysaccharide, Cassia fistula, Xanthan, Cucurbita maxima pulp powder, Hibiscus rosa-sinensis Linn. Mucilage and Mango Peel Pectin. Synthetic Superdisintegrants includes Cross-linked polyvinyl pyrrolidone (crospovidone, Polyplasdone XL, XL10), Microcrystalline Cellulose (Avicel), Modified Cellulose (croscarmellose sodium, Ac-Di-Sol), Sodium Starch Glycolate (Explotab, Primogel), Resins, Calcium Silicate and Ion exchange resins....
Nature has provided us a wide variety of materials to help improves and sustains the health of all living things either directly or indirectly. Many herbal medicines have been recommended for the disease. Many polysaccharides have been finding, very interesting and useful application in the biopharmaceutical field. A large number of plant based excipients are available today. They have been extensively explored as pharmaceutical excipients. Fenugreek gum is one of them that have wide potentiality in drug formulation due to its extensive application as food additive and its recognized lack of toxicity. Through the keen references of reported literature on fenugreek gum. We have described critical aspects of fenugreek seed mucilage, its manufacturing process, physicochemical properties and application in various drug delivery systems....
Genipin, a crystalline and well defined chemical compound, is extracted from gardenia fruits according to a modern microbiological process. The components of the fruit have been used in traditional Chinese medicine and as a blue colorant by food industries in East Asia. Because it is a naturally occurring, biodegradable molecule with low cytotoxicity, genipin has recently been investigated as a crosslinking material in many biological applications. Recent explorations into the use of genipin crosslinked gelatin for the use as a bioadhesive, wound dressing, and as bone substitutes, have shown it to have potential as a new and safe crosslinking agent. The most common crosslinking agent has been glutaraldehyde, but because of concerns about its toxicity new methods are being tested like genipin. In the area of forensic science, genipin is being examined as a new way of developing latent fingerprints on paper products....
Guar gum is a natural nonionic polysaccharide derived from the seeds of Cymompsis tetraganolobus (family: Leguminaceae). Chemically, guar gum is a galactomannan type of polysaccharide having very high molecular weight. Due to its unique rheology modifying properties, it is being widely used across a broad spectrum of industries viz. oil well drilling, textile, paper, paint, cement, cosmetic, food, pharmaceutical etc. The aim of this review is to give a brief overview to the role of natural polymer in the development of drug delivery system. The use of guar gum is valuable based on proven biocompatibility and safety. Guar gum is most popular polysaccharide polymer because of their cost-effectiveness and regulatory acceptance. Moreover, guar gum is safe, nontoxic, biodegradable, easy availability and capable of chemical modification to deliver active pharmaceutical ingredients. The wider application of guar gum is due to its unique features such as high swelling, water retention capacity, high viscosity properties and abundant availability....
In recent era various technologies have been made in research and development of controlled release oral drug delivery system to overcome various physiological difficulties such as variation in gastric retention and emptying time. To overcome this drawback and to maximize the oral absorption of various drugs, novel drug delivery systems have been developed. Gastroretentive drug delivery system is facing many challenges which can be overcome by upcoming emerging approach i.e. low density system. Kollidon SR is an example of low density system which combines the properties like buoyancy through generation of a high porosity in the tablet, binding effect, flow aid, release slowing effect. This review attempt to discuss Kollidon SR properties, formulation and development of floating tablet based on Kollidon SR matrixes, effect of curing on hardness and drug release from Kollidon SR matrixes and various analytical methods for Kollidon SR....
Okra gum is natural polysaccharide derived from the pods of Abelmoschus esculentus (L.) Moench belongs to the malvaceae plant family. Okra gum also known as lady’s fingers, gombo, bamia. Chemically, okra gum is polysaccharide consists of a repeating unit of alternating rhamnose and galacturonic acid residues. Recently natural polymers are widely used because of their enormous advantages over synthetic polymers like biocompatibility, easy availability and economically more sound. Okra polysaccharide extracts were isolated and their capacity to affect the rheology and stability of emulsion. It is used as an emulsifier, stabilizer and also as a solubility enhancer. The aim of review is to give a brief overview to the role of natural polymer in the development of drug delivery system. This review spotlights the information about various uses of okra gum and also focus on their advantages properties and applicability. Okra gum is used in the controlled release dosage forms it is not suitable for conventional dosage form....
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